Table 2.
Target clinical domain for the included rcts according to medical subject headings (MeSH) category extracted from AACT (n = 393)
| Target Domain Category [MeSH Category] | Count | % |
|---|---|---|
| C23: Pathological Conditions, Signs and Symptoms | 144 | 36.6 |
| C04: Neoplasms | 142 | 36.1 |
| C10: Nervous System Diseases | 91 | 23.2 |
| C14: Cardiovascular Diseases | 67 | 17.0 |
| C20: Immune System Diseases | 61 | 15.5 |
| C06: Digestive System Diseases | 58 | 14.8 |
| C17: Skin and Connective Tissue Diseases | 57 | 14.5 |
| C12: Male Urogenital Diseases | 39 | 9.9 |
| C13: Female Urogenital Diseases and Pregnancy Complications | 39 | 9.9 |
| C08: Respiratory Tract Diseases | 38 | 9.7 |
| C15: Hemic and Lymphatic Diseases | 37 | 9.4 |
| C16: Congenital, Hereditary, and Neonatal Diseases and Abnormalities | 35 | 8.9 |
| C18: Nutritional and Metabolic Diseases | 35 | 8.9 |
| C19: Endocrine System Diseases | 26 | 6.6 |
| F03: Mental Disorders | 25 | 6.4 |
| C01: Bacterial Infections and Mycoses | 14 | 3.6 |
| C02: Virus Diseases | 10 | 2.5 |
| C05: Musculoskeletal Diseases | 10 | 2.5 |
| D27: Chemical Actions and Uses | 8 | 2.0 |
| C25: Chemically Induced Disorders | 6 | 1.5 |
| F02: Psychological Phenomena | 6 | 1.5 |
| G04: Cell Physiological Phenomena | 6 | 1.5 |
| G11: Musculoskeletal and Neural Physiological Phenomena | 6 | 1.5 |
| C07: Stomatognathic Diseases | 5 | 1.3 |
| C11: Eye Diseases | 5 | 1.3 |
| C26: Wounds and Injuries | 4 | 1.0 |
| G07: Physiological Phenomena | 4 | 1.0 |
| D02: Organic Chemicals | 3 | 0.8 |
| D04: Polycyclic Compounds | 3 | 0.8 |
| D12: Amino Acids, Peptides, and Proteins | 3 | 0.8 |
| E01: Diagnosis | 3 | 0.8 |
| E05: Investigative Techniques | 3 | 0.8 |
| F01: Behavior and Behavior Mechanisms | 3 | 0.8 |
| D10: Lipids (Amino Acids, Peptides, and Proteins) | 2 | 0.5 |
| B04: Viruses | 1 | 0.3 |
| C09: Otorhinolaryngologic Diseases | 1 | 0.3 |
| D01: Inorganic Chemicals | 1 | 0.3 |
| D06: Hormones, Hormone Substitutes, and Hormone Antagonists | 1 | 0.3 |
| D09: Carbohydrates (Lipids) | 1 | 0.3 |
| D23: Biological Factors | 1 | 0.3 |
| E04: Surgical Procedures, Operative | 1 | 0.3 |
| J02: Food and Beverages | 1 | 0.3 |
| N06: Environment and Public Health | 1 | 0.3 |
MeSH = medical subject headings.
A single RCT may have multiple target domains.