TABLE 2.
AmB concentrations in bronchial-wash fluid after aerosol administration
| Dose | Concn (ng/ml) at:
|
AUCa (ng · h/ml) | |||||
|---|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 3 h | 5 h | 12 h | 24 h | ||
| 5 mg | |||||||
| Sheep 1 | 74.0 | 62.4 | 45.5 | 87.6 | 25.5 | 25.0 | 240.0 |
| Sheep 2 | 300.0 | 53.3 | 59.7 | 67.1 | 10.5 | 20.5 | 403.1 |
| Sheep 3 | 173.0 | 148.0 | 44.4 | 64.5 | 16.9 | 22.1 | 709.0 |
| Sheep 4 | 388.0 | 78.4 | 59.0 | 20.9 | 20.3 | 20.8 | 575.1 |
| Mean ± SD (n = 4) | 233.8 ± 138.3 | 85.5 ± 42.9 | 45.5 ± 19.2 | 60.0 ± 28.1 | 18.3 ± 6.3 | 22.1 ± 2.0 | 481.8 ± 204.1 |
| 30 mg | |||||||
| Sheep 1 | 242.0 | 199.0 | 165.0 | 115.0 | 43.0 | 42.0 | 1,367.8 |
| Sheep 2 | 156.0 | 63.6 | 82.7 | 172.0 | 26.2 | 24.1 | 1,188.6 |
| Sheep 3 | 255.0 | 102.0 | 161.0 | 67.5 | 45.7 | 23.6 | 1,040.7 |
| Mean ± SD (n = 3) | 217.7 ± 53.8 | 121.5 ± 69.8 | 136.2 ± 46.4 | 118.2 ± 52.3 | 38.3 ± 10.6 | 29.9 ± 10.4 | 1,199.0 ± 163.8 |
a
From 0 to 24 h.