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. 2023 Sep 27;13:1263556. doi: 10.3389/fonc.2023.1263556

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Copyright © 2023 Stasenko, Kaestner, Rodriguez, Kohli, Farid, Goodwill, Schwartz, Schulte and McDonald

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the classic Papez circuit—a medial limbic network important for episodic memory. Information from cortical association areas is sent to the hippocampus via the cingulate gyrus, parahippocampal gyrus/entorhinal cortex, and cingulum bundle (white matter fibers). Processed information from the hippocampus is sent via the fornix (green) to the mammillary bodies of the hypothalamus. Information from the mammillary bodies is sent to the anterior nuclei of the thalamus via the mammillothalamic tract, which then projects fibers to the cingulate gyrus, parahippocampal gyrus/entorhinal cortex, and cingulum back to the hippocampus.