Table 3.
Variable | Univariate | Multivariate | |||||||
---|---|---|---|---|---|---|---|---|---|
OR | 95%CI Lower |
95%CI Upper |
p | OR | 95%CI Lower |
95%CI Upper |
p | ||
CR before AHSCT | 23.10 | 2.53 | 210.89 | 0.0054 | 38.55 | 3.04 | 489.24 | 0.0048 | |
≥2 lines before AHSCT | 0.31 | 0.07 | 1.27 | 0.1027 | |||||
Cytogenetic risk group | Unknown | Reference | |||||||
Standard Risk | 0.21 | 0.02 | 1.90 | 0.1662 | |||||
High Risk | 1.71 | 0.22 | 13.56 | 0.6094 | |||||
Maintenance treatment | 0.65 | 0.06 | 6.72 | 0.7145 | |||||
Melphalan dose | Mel 200 | 0.60 | 0.18 | 2.01 | 0.4028 | ||||
Reduced dose | Reference | ||||||||
Induction regimen | Bortezomib-based | 2.89 | 0.69 | 12.02 | 0.1448 | ||||
ISS | I/II | Reference | |||||||
III | 0.25 | 0.06 | 1.06 | 0.0596 | |||||
Age | <60 | Reference | |||||||
>60 | 0.49 | 0.15 | 1.63 | 0.2438 | |||||
Paraprotein type | Other | Reference | |||||||
LCD | 1.00 | 0.22 | 4.61 | 1.0000 | |||||
hsa-miR-221-3p T1 | 2.97 | 0.83 | 10.59 | 0.0926 | |||||
hsa-miR-15b-5p T1 | 0.78 | 0.36 | 1.70 | 0.5329 | |||||
hsa-miR-223-3p T1 | 5.76 | 1.63 | 20.28 | 0.0065 | 4.72 | 1.14 | 19.59 | 0.0327 | |
hsa-miR-320c T1 | 0.73 | 0.26 | 2.10 | 0.5647 | |||||
hsa-miR-361-3p T1 | 0.82 | 0.29 | 2.27 | 0.6954 | |||||
hsa-miR-150-5p T1 | 1.37 | 0.63 | 2.98 | 0.4222 | |||||
hsa-miR-221-3p T2 | 3.57 | 1.09 | 11.75 | 0.0362 | 3.29 | 0.61 | 17.76 | 0.1659 | |
hsa-miR-15b-5p T2 | 1.18 | 0.51 | 2.73 | 0.6936 | |||||
hsa-miR-223-3p T2 | 1.70 | 0.84 | 3.44 | 0.1390 | |||||
hsa-miR-320c T2 | 0.76 | 0.37 | 1.58 | 0.4628 | |||||
hsa-miR-361-3p T2 | 1.30 | 0.75 | 2.26 | 0.3432 | |||||
hsa-miR-150-5p T2 | 0.92 | 0.48 | 1.73 | 0.7903 |