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. 2023 Sep 1;43(10):1143–1163. doi: 10.1002/cac2.12480

FIGURE 2.

FIGURE 2

The molecular characterization of CD103+CD8+ TILs. (A) GO analysis of gene set from the CD8+ TILs subtypes. (B) KEGG analysis of gene set from CD8+ TILs subtypes. (C) PID analysis of gene set from the CD8+ TILs subtypes. (D) Heatmap depicting the cell‐type‐specific markers in the CD8+ TILs subtypes. (E) FACS analysis of gene expression in CD103+CD8+ T cells and CD103−CD8+ T cells from advanced HNSCC tissues (n = 4). (F) FACS analysis of CD103+CD8+ T cell population in PBMC (B), responders (R) and non‐responders (NR) tumor tissues, respectively (n = 10). Horizontal bar indicates the median. Significance was determined with an unpaired 2‐tailed student's t‐test or one‐way ANOVA with Bonferroni post hoc test. Abbreviations: TIL, tumor‐infiltrating cell; HNSCC, head and neck squamous cell carcinoma; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; PID, Pathway Interaction Database; IL‐2, Interleukin 2; TNF‐α, tumor necrosis factor; GZMB, Granzyme B; CXCL13, C‐X‐C motif chemokine ligand 13; PD‐1, programmed cell death protein‐1; CCR7, C‐C Motif Chemokine Receptor 7; PBMC, peripheral blood mononuclear cell; FACS, flow cytometry.