Table 1. . Routine serologies measured on patient pre-ipilimumab/nivolumab, pre-radiation therapy, pre-chemotherapy, and 3 months after the start of chemotherapy.
| Preimmunotherapy | Preradiotherapy | Prechemotherapy | 3 months after chemotherapy start | |
|---|---|---|---|---|
| WBC | 5.68 | 5.38 | 8.34 | 5.52 k/µl |
| Hgb | 8.6 | 10.7 | 9.8 | 9.7 g/dl |
| Plts | 203 | 189 | 218 | 169 k/µl |
| Absolute neutrophil | 4.00 | 3.26 | 6.35 | 3.98 k/µl |
| Relative neutrophil | 70.3 | 60.5 | 76.1 | 72.0% |
| Absolute eosinophil | 0.09 | 0.09 | 0.20 | 0.14 k/µl |
| Relative eosinophil | 1.6 | 1.7 | 2.4 | 2.5% |
| Absolute monocyte | 0.35 | 0.44 | 0.50 | 0.39 k/µl |
| Relative monocyte | 6.2 | 8.2 | 6.0 | 7.1% |
| Absolute lymphocyte | 1.18 | 1.57 | 1.24 | 0.98 k/µl |
| Relative lymphocyte | 20.8 | 29.2 | 14.9 | 17.8% |
| Erythrocyte sedimentation rate | 68 | 19 | 30 | |
| LDH | 333 | 425 | 226 | 172 U/l |
| ALT | 19 | 12 | 14 | 38 U/l |
| AST | 24 | 17 | 15 | 18 U/l |
| Alkaline phosphatase | 55 | 46 | 51 | 62 U/l |
| T Bili | 0.50 | 0.30 | 0.64 | 0.40 mg/dl |
| Cr | 0.5 | 0.6 | 0.5 | 0.5 mg/dl |
| BUN | 8 | 15 | 11 | 10 mg/dl |
| Na | 139 | 140 | 139 | 139 mmol/l |
| K | 4.3 | 4.2 | 4.4 | 4.2 mmol/l |
| Cl | 100 | 102 | 105 | 102 mmol/l |
Bold values represent the inflammatory state of the patient. ESR was elevated, and LDH was elevated before treatment.
LDH, a marker of inflammation decreased 3 months after the start of chemotherapy.
ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; Cl: Chloride; Cr: Creatinine; Hgb: Hemoglobin; K: Potassium; LDH: Lactate dehydrogenase; Na: Sodium; Plt: Platelet; T bili: Total bilirubin; WBC: White blood cell.