Table 1.

Potential risk factors for insufficient treatment outcomes following liver transplantation

Risk factor	Strategies to overcome
Morphometric variable (outside Milan criteria)	Incorporation of expanded criteria combined with markers (Table 4)
Tumor size	Downstaging with logoregional therapy (TACE, TARE, RT)
Tumor number
Tumor marker	Incorporation of expanded criteria combined with markers (Table 4)
AFP	Downstaging with logoregional therapy (TACE, TARE, RT)
PIVKA-II
Serum inflammation marker	Incorporation of expanded criteria combined with markers (Table 4)
Neutrophil-to-lymphocyte ratio	Downstaging with logoregional therapy (TACE, TARE, RT)
C-reactive protein
Imaging marker	Incorporation of expanded criteria combined with markers (Table 4)
Positive PET-CT	Downstaging with logoregional therapy (TACE, TARE, RT)

AFP, alpha-fetoprotein; PIVKA-II, prothrombin-induced by vitamin K absence or antagonist-II; TACE, trans-arterial chemoembolization; TARE, trans-arterial radioembolization; RT, radiotherapy; PET-CT, positron emission tomography-computed tomography.