Table 4.

Univariate and multivariate analysis for overall and cancer-specific survival in matched cohort

		Overall survival				Cancer-specific survival
		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
		OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Sex, male		1.45 (0.77-2.73)	0.254			1.29 (0.55-3.03)	0.562
Age, ≥70 years		1.22 (0.77-1.95)	0.396			1.78 (0.94-3.19)	0.052
BMI, ≥30 kg/m2		1.08 (0.69-1.69)	0.732			0.94 (0.52-1.69)	0.839
HBV		0.88 (0.56-1.38)	0.572			0.71 (0.40-1.27)	0.248
HCV		1.12 (0.52-2.42)	0.780			0.85 (0.26-2.74)	0.78
Alcoholic liver disease		2.38 (1.02-5.53)	0.044			1.97 (0.71-5.50)	0.195
ICG-R15, ≥20%		0.87 (0.53-1.42)	0.566			0.80 (0.41-1.57)	0.514
AFP, ≥200 ng/mL		1.26 (0.81-1.97)	0.297			1.07 (0.59-1.93)	0.827
PIVKA-II, ≥500 mAU/mL		1.47 (0.94-2.31)	0.090			1.29 (0.73-2.29)	0.381
Tumor number 2 or more on pathology		1.41 (0.91-2.17)	0.122			0.97 (0.55-1.72)	0.921
Tumor size 5 cm or larger on pathology		1.31 (0.85-2.01)	0.220			1.39 (0.78-2.47)	0.264
Differentiation
	Worst, IV vs. I-III	1.15 (0.74-1.78)	0.537			1.73 (0.96-3.11)	0.066
	Major, IV vs. I-III	1.31 (0.66-2.63)	0.443			2.06 (0.96-4.41)	0.064
Microvascular invasion		1.63 (0.99-2.70)	0.057			1.68 (0.85-3.29)	0.133
Intrahepatic metastasis		2.18 (1.37-3.46)	0.001	2.06 (1.25-3.41)	0.005	1.41 (0.75-2.65)	0.281	1.99 (1.04-3.80)	0.038
Anatomical resection		1.46 (0.75-2.83)	0.261			1.14 (0.48-2.67)	0.771
Transfusion		1.77 (1.07-2.93)	0.027	1.77 (1.01-3.11)	0.046	1.36 (0.70-2.68)	0.367

Values are presented as median (range).

OR, odds ratio; CI, confidence interval; BMI, body mass index; HBV, hepatitis B virus; HCV, hepatitis C virus; ICG, indocyanine green; AFP, alphafetoprotein; PIVKA-II, protein induced by vitamin K absence-II.