Inhibition of biofilm formation of Staphylococcus aureus and Candida albicans and dispersion of preformed biofilms of S. aureus by sporothioether mixture (14 and 15) and sporothriolide 8 at various concentrations; references [%].
| Test organism | 14 + 15 mixture | 8 | |
|---|---|---|---|
| Biofilm inhibition [% ± SD] | S. aureus (DSM 1104)a | 77 ± 9 (250 μg mL−1) | 75 ± 8 (250 μg mL−1) |
| 24 ± 9 (62.5 μg mL−1) | 55 ± 9 (3.9 μg mL−1) | ||
| 37 ± 10 (2 μg mL−1) | |||
| C. albicans (DSM 11225)b | 58 ± 8 (250 μg mL−1) | — | |
| 40 ± 10 (31.3 μg mL−1) | |||
| Biofilm dispersion [% ± SD] | S. aureus (DSM 1104)c | 77 ± 9 (250 μg mL−1) | 53 ± 6 (250 μg mL−1) |
| 24 ± 9 (62.5 μg mL−1) | 36 ± 5 (62.5 μg mL−1) | ||
Microporenic acid A, 74 ± 12 (250 μg mL−1), 75 ± 6 (7.8 μg mL−1), 42 ± 7 (3.9 μg mL−1).
Farnesol: 75 ± 9 (250 μg mL−1), 51 ± 7 (31.3 μg mL−1), 38 ± 10.
Microporenic acid A: 64 ± 7 (250 μg mL−1), 41 ± 15 (15.6 μg mL−1); SD: standard deviation; —no inhibition.