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. 2023 Oct 11;13(42):29768–29772. doi: 10.1039/d3ra06542a

Inhibition of biofilm formation of Staphylococcus aureus and Candida albicans and dispersion of preformed biofilms of S. aureus by sporothioether mixture (14 and 15) and sporothriolide 8 at various concentrations; references [%].

Test organism 14 + 15 mixture 8
Biofilm inhibition [% ± SD] S. aureus (DSM 1104)a 77 ± 9 (250 μg mL−1) 75 ± 8 (250 μg mL−1)
24 ± 9 (62.5 μg mL−1) 55 ± 9 (3.9 μg mL−1)
37 ± 10 (2 μg mL−1)
C. albicans (DSM 11225)b 58 ± 8 (250 μg mL−1)
40 ± 10 (31.3 μg mL−1)
Biofilm dispersion [% ± SD] S. aureus (DSM 1104)c 77 ± 9 (250 μg mL−1) 53 ± 6 (250 μg mL−1)
24 ± 9 (62.5 μg mL−1) 36 ± 5 (62.5 μg mL−1)
a

Microporenic acid A, 74 ± 12 (250 μg mL−1), 75 ± 6 (7.8 μg mL−1), 42 ± 7 (3.9 μg mL−1).

b

Farnesol: 75 ± 9 (250 μg mL−1), 51 ± 7 (31.3 μg mL−1), 38 ± 10.

c

Microporenic acid A: 64 ± 7 (250 μg mL−1), 41 ± 15 (15.6 μg mL−1); SD: standard deviation; —no inhibition.