Minimal inhibitory concentrations (MIC) of sporothioether mixtures (14 and 15; 24 and 25) dissolved in MeOH, sporothriolide 8 and control drugs.
| Test organism | MIC [μg ml−1] | |||
|---|---|---|---|---|
| 14 and 15 mix | 24 and 25 mix | 8 (ref. 9) | Ref. | |
| Schizosaccharomyces pombe (DSM 70572) | 66.6 | — | 8.3 | 4.2a |
| Pichia anomala (DSM 6766) | — | — | 33.3 | 8.3a |
| Mucor hiemalis (DSM 2656) | 66.6 | — | 4.2 | 4.2a |
| Candida albicans (DSM 1665) | — | — | 16.6 | 8.3a |
| Rhodotorula glutinis (DSM 10134) | — | — | 16.6 | 2.1a |
| Acinetobacter baumannii (DSM 30008) | — | — | nt | 0.26b |
| Escherichia coli (DSM 1116) | — | — | — | 1.7c |
| Bacillus subtilis (DSM 10) | — | — | — | 8.3c |
| Mycobacterium smegmatis (ATCC 700084) | — | — | nt | 1.7d |
| Staphylococcus aureus (DSM 346) | — | — | — | 1.7c |
| Pseudomonas aeruginosa (PA 14) | — | — | — | 0.42e |
| Chromobacterium violaceum (DSM 30191) | — | — | nt | 0.42c |
a
Nystatin.
b
Ciprobay.
c
Oxytetracyclin hydrochloride.
d
Kanamycin.
e
Gentamycin; – no inhibition; nt, not tested. The cell density was adjusted to 8 × 106 cells per ml.