Table 3. Longitudinal COGA Cohort (nā=ā2818) Results From Cox Proportional Hazards Models for Progression to Severe AUDa.
| No criteria | Prior single criterion | Prior mild AUD (2-3 criteria) | Prior moderate AUD (4-5 criteria) | Prior mild-to-moderate | |||
|---|---|---|---|---|---|---|---|
| Endorsed only low-risk criteria | Endorsed ā„1 high-risk criterion | Total | |||||
| Sample size, No. | 1236 | 566 | 833 | 183 | 699 | 317 | 1016 |
| Proportion progressing to severe AUD (ā„6 criteria), % (95% CI) | 2.6 (1.8-3.6) | 4.2 (2.9-6.3) | 15.4 (13.1-18.0) | 37.2 (30.4-44.4) | 12.9 (10.6-15.6) | 33.4 (28.5-38.8) | 19.3 (17.0-21.8) |
| Adjusted Cox proportional hazards ratio (95% CI) | NA | 1.13 (0.66-1.93) | 3.43 (2.33-5.05) | 11.10 (7.17-17.20) | 5.64 (3.28-9.70) | 11.62 (7.53-17.92) | 11.30 (7.33-17.43) |
Abbreviations: AUD, alcohol use disorder; COGA, Collaborative Study on the Genetics of Alcoholism; NA, not applicable.
a
All Cox proportional hazards models included sex and race and ethnicity as covariates clustered within family. Mild and moderate AUD models additionally included dummy-coded variables for criterion count (ie, 0/1 for 2 vs 3 criteria for mild; 0/1 for 4 vs 5 criteria for moderate). Mild-to-moderate AUD models additionally included dummy-coded variables for criterion count for 2 to 5 criteria.