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. 2023 Aug 17;15(10):e17094. doi: 10.15252/emmm.202217094

Figure 3. Fbxw7 hotspot mutation drives enrichment of LEF1 signalling in GEMM uteri and human cancer cells.

Figure 3

  1. (Left panel) Schematic illustrating gene expression profiling of mouse uterine samples of indicated genotypes and group sizes at 8 weeks age, with groups compared by enrichment analysis. (Right panel) Dot plot indicating enrichment of MSigDB C6 oncogenic gene sets in Pten del; Fbxw7 mut uteri vs. Pten del uteri. Arrows indicate enrichment of LEF1 signatures.
  2. (Left panel) Schematic illustrating comparison of high‐risk endometrial cancers from UCEC and UCS cohorts (see Results for definition) by enrichment analysis according to pathogenic FBXW7 missense mutation status. (Right panel) Dot plot indicating enrichment of MSigDB C6 signatures in FBXW7 mutant tumours. Arrows indicate enrichment of LEF1 signatures.
  3. (Left panel) Schematic illustrating comparison of isogenic parental FBXW7 wild‐type (FBXW7 +/+) and heterozygous WD40 hotspot missense mutant (FBXW7 R505C/+) isogenic HCT116 cells reported by Thirimanne et al (2022) by enrichment analysis following pre‐ranking. (Right panel) Dot plot indicating enrichment of MSigDB C6 oncogenic sets in FBXW7 R505C/+ cells. Arrows indicate enrichment of LEF1 signatures.

Source data are available online for this figure.