Table 1.

Functional roles of 10 hub genes.

No.	Gene symbol	Full name	Function
1	IL6	Interleukin 6	A cytokine that functions in inflammation and the maturation of B cells.
2	IL10	Interleukin 10	A cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation.
3	CXCL9	C–X–C motif chemokine ligand 9	The protein encoded is thought to be involved in T-cell trafficking. The encoded protein binds to C–X–C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils.
4	ITGAM	Integrin subunit alpha M	This gene encodes the integrin alpha M chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin. The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium and in the phagocytosis of complement coated particles.
5	CCL5	C–C motif chemokine ligand 5	This gene is one of the several chemokine genes clustered on the q-arm of chromosome 17. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T-helper cells, and eosinophils.
6	CD4	CD4 molecule	The CD4 membrane glycoprotein acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules.
7	IDO1	Indoleamine 2,3-dioxygenase 1	A heme enzyme that acts on multiple tryptophan substrates. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity.
8	HAVCR2	Hepatitis A Virus Cellular Receptor 2	The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns.
9	TLR9	Toll-like receptor 9	The protein encoded by this gene is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.
10	CCR7	C–C motif chemokine receptor 7	The protein encoded by this gene is a member of the G protein–coupled receptor family. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.