FIG. 3.

Comparative effects of ACV and BILD 1633 SE against HSV-1 PAA^r5 infection. Animals were cutaneously inoculated with 10⁶ PFU/site, as described in Materials and Methods. ACV (5%) and BILD 1633 SE (5%) were applied topically four times per day. (A) Mean lesion scores. The mean lesion score was significantly reduced by ACV treatment on days 12-14 (n = 10; P < 0.05) and was further reduced by BILD 1633 SE on days 10 to 24 (n = 24; the result was significantly different [P < 0.05] from those for all other groups). (B) AUCs of the lesion scores. The AUCs of lesion scores are presented as means ± SEMs. ∗, P < 0.05 compared with the results for all other groups.