FIG. 4.

Effects of BILD 1633 SE and ACV against HSV-1 PAA^r5 infection. Animals were cutaneously inoculated with 10⁷ PFU/site, as described in Materials and Methods. (A and B) BILD 1633 SE and ACV were applied in 5% topical formulation. (C and D) BILD 1633 SE was applied four times a day at concentrations of 0, 0.8, 2, and 5%. The AUCs of the lesion scores are presented as means ± SEMs (n = 12). ∗, P < 0.05 compared with the results for the vehicle group; †, P < 0.05 compared with the results for the vehicle and 0.8% BILD 1633 SE groups.