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. Author manuscript; available in PMC: 2023 Oct 11.
Published in final edited form as: Psychoneuroendocrinology. 2023 Mar 15;152:106084. doi: 10.1016/j.psyneuen.2023.106084

Table 3.

Summary of findings from studies examining metabolic and cardiovascular diagnoses and events.

Study Design Sample description Type of separation Type of outcomes & Age(s) at outcome Covariates Findings (main effects, moderation by sex, age at and duration of separation) Effect size(s) for main effects

Ahrens et al., 2014 Prospective Sub-sample from the Midwest Evaluation of the Adult Functioning of Former Foster Youth (n= 596), and a non-exposed, economically-secure group matched for age (n=1461) drawn from the National Longitudinal Study of Adolescent Health (AddHealth) Foster care; self-port and record Diabetes; Self-report Age range: 25–26 Sex Race, ethnicity Age at adult assessment Attained education level in adulthood Economic insecurity at adult assessment Past or current pregnancy No difference in reports of diabetes between foster care group and economically-secure control group. Moderation by sex: none. NA
Alastalo et al., 2009 Prospective Simple random sample of the Helsinki Birth Cohort: Separated group (n=320), non-separated group (n=1683) War evacuation; self-report and record Cardiovascular disease Type 2 diabetes Chronic diseases (via meds); self-report use of medication and physician diagnoses Mean age: 62 Sex Father’s occupation status in childhood Age at adult assessment Attained education level in adulthood War evacuees displayed higher risk for any cardiovascular disease and type 2 diabestes. Moderation by sex: not significant. Effects of age at evacuation: not significant. Effects of duration of evacuation: Positive relations between longer period of evacuation and greater cardiovascular disease risks. ORs= 1.5 (CI= 1.0 to 2.0) to 1.7 (CI=1.1, 2.4)
Alastalo et al., 2012 Prospective The Helsinki Birth Cohort: separated group (n=1726), non-separated group (n=11189) War evacuation; record Medication for CHD Hospital admission or death for coronary event or stroke Cardiovascular mortality; record Mean age: 64 Analyses were stratified by year of birth and by sex Adjusted for father’s occupation status in childhood War evacuation associated with greater use of medication for CHD, though no association with the other outcomes. Effects of age at evacuation: Early childhood period (ages 4–7) associated with greater risk for CHD medication only. Effects of duration of separation: Risk for CHD was higher if subjects were separated 1–3 years compared to non-separated. Effect not seen for those separated for <1 or >3 years. HRs= .94 (CI= .72, 1.21) to 1.29 (CI= 1.04, 1.59)
Xie et al., 2021 Prospective Data from the National Child Development Study in the UK: Separated group (n=420), non-separated group (n=10740) Out of home care; parent-report Diabetes; self-report Mean age: 42 Sex Childhood SES Health conditions No differences in self-report daibetes in bivariate and adjusted analyses. OR= .50 (CI= .10, 1.5)

Note. CHD= Coronary heart disease. ORs= odds ratios. HRs= hazard ratios. CI= confidence interval. NA= not available because the effect sizes and/or information that could be used to calculate effect sizes are not available in the article.