Comparison 2. Sensitivity analyses: Cerebrolysin or Cortexin versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 All‐cause death. Sensitivity 1. Best‐case	6	1689	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.65, 1.41]
2.1.1 Cerebrolysin dose: 30 mL for 10 days	3	1235	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.56, 1.39]
2.1.2 Cerebrolysin dose: 50 mL for 21 days	1	146	Risk Ratio (M‐H, Fixed, 95% CI)	0.87 [0.29, 2.58]
2.1.3 Cerebrolysin dose: 10 mL and 50 mL for 10 days	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [0.37, 3.73]
2.1.4 Cortexin dose: 20 mg for 10 days, 10 days rest, then 20 mg for 10 days	1	168	Risk Ratio (M‐H, Fixed, 95% CI)	2.17 [0.12, 39.28]
2.1.5 Cortexin dose: 20 mg for 10 days, 10 days rest, then placebo for 10 days	1	104	Risk Ratio (M‐H, Fixed, 95% CI)	3.16 [0.17, 59.53]
2.2 All‐cause death. Sensitivity 2. Worst‐case	6	1689	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.66, 1.00]
2.2.1 Cerebrolysin dose: 30 mL for 10 days	3	1235	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.65, 1.02]
2.2.2 Cerebrolysin dose: 50 mL for 21 days	1	146	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.24, 1.12]
2.2.3 Cerebrolysin dose: 10 mL and 50 mL for 10 days	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [0.37, 3.73]
2.2.4 Cortexin dose: 20 mg for 10 days, 10 days rest, then 20 mg for 10 days	1	168	Risk Ratio (M‐H, Fixed, 95% CI)	2.17 [0.12, 39.28]
2.2.5 Cortexin dose: 20 mg for 10 days, 10 days rest, then placebo for 10 days	1	104	Risk Ratio (M‐H, Fixed, 95% CI)	3.16 [0.17, 59.53]
2.3 All‐cause death. Sensitivity 3. Complete case (missing data excluded)	6	1496	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.63, 1.35]
2.3.1 Cerebrolysin dose: 30 mL for 10 days	3	1054	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.54, 1.33]
2.3.2 Cerebrolysin dose: 50 mL for 21 days	1	134	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.27, 2.31]
2.3.3 Cerebrolysin dose: 10 mL and 50 mL for 10 days	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [0.37, 3.73]
2.3.4 Cortexin dose: 20 mg for 10 days, 10 days rest, then 20 mg for 10 days	1	168	Risk Ratio (M‐H, Fixed, 95% CI)	2.17 [0.12, 39.28]
2.3.5 Cortexin dose: 20 mg for 10 days, 10 days rest, then placebo for 10 days	1	104	Risk Ratio (M‐H, Fixed, 95% CI)	3.16 [0.17, 59.53]
2.4 All‐cause death. Sensitivity 4. Risk of bias	6	1689	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.65, 1.41]
2.4.1 Low and unclear risk of bias	3	354	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.51, 3.21]
2.4.2 High risk of bias for incomplete outcome data	3	1335	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.59, 1.38]