. 1998 Jul;42(7):1646–1653. doi: 10.1128/aac.42.7.1646

TABLE 4.

Correlation between the amount of tretinoin recovered in each lipoprotein fraction and lipid and protein concentrations and compositions in plasma lipoprotein from humans, dogs, and rats following incubation with [³H]ATRA and [³H]Atragen^a

Drug and lipoprotein component or ratio^a	Correlation with amt of tretinoin recovered from^b:
Drug and lipoprotein component or ratio^a	TRL fraction	LDL fraction	HDL fraction
[³H]ATRA
TC	0.99^d	0.91^d	0.95^d
TG	0.98^d	0.79^d	0.24^e
TP	0.88^d	0.04^e	−0.49^e
TC/TP	0.87^d	0.59^e	0.95^d
TG/TP	−0.12^e	0.51^e	−0.15^e
TG/TC	−0.88^d	0.20^e	−0.60^e
[³H]Atragen
TC	0.92^d	0.91^d	0.92^d
TG	0.90^d	0.71^d	0.53^e
TP	0.86^d	−0.22^e	−0.57^e
TC/TP	0.29^e	0.68^e	0.98^d
TG/TP	−0.44^e	0.35^e	0.14^e
TG/TC	−0.64^e	−0.10^e	−0.47^e

[³H]ATRA or [³H]Atragen was incubated at a concentration of 25 μg of tretinoin/ml in either human, dog, or rat plasma for 60 min at 37°C.

TC, total cholesterol; TG, total triglycerides; TP, total protein.

Data are given as Pearson correlation coefficients (r) between amount of tretinoin associated with lipoproteins and lipid and protein concentrations and compositions in plasma lipoproteins.

Significant at P < 0.05.

Not significant.