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. 2023 Oct 11;28:421. doi: 10.1186/s40001-023-01373-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Pathological manifestations of Omicron (B.1.1.529) infection in Syrian hamster and hACE2.Tg mice. Pathological manifestations of intranasal Omicron (B.1.1.529) infection was evaluated and compared with ancestral Wuhan (nCoV-2019) and Delta (B.1.617.2) strain infection or uninfected (UI) in Syrian hamster and hACE2.Tg mice. The changes in body mass was plotted as percentage of the day 0 body mass till day 14 or 6 post infection, respectively, for (A) hamster and (F) hACE2.Tg mice. The lungs of the sacrificed animals were harvested and images and thereafter, viral load and histopathology of the lungs were studied. B and G Shows representative lungs from individual groups at 4 dpi and 6 dpi from hamster and hACE2.Tg mice, respectively. C and H Viral load of the lungs at 4dpi and 6 dpi from hamster and hACE2.Tg mice, respectively. D–E and I–J Histopathological assessment of the HE stained lungs were carried out by trained pathologist by blinded scoring on the scale of 0–5 (where 0 described no feature and 5 described highest pathological feature) of the lungs at 4 dpi and 6 dpi from hamster and hACE2.Tg mice, respectively. Each experiment was carried out with n = 5 animals and replicated 3 times independently. One-way ANOVA using non-parametric Kruskal–Wallis test for multiple comparison. ns = non-significant, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001