Table 1.

CD22 ADC/recombinant immunotoxin structures

ADC/recombinant immunotoxin	Anti-CD22 antibody	Cytotoxic payload	Linker	Disease
BL22	RFB4 dsFv	Pseudomonas exotoxin A (PE38)	mc-VC-PABC (enzyme cleavable)	R/R HCL
Moxetumomab pasudotox/HA22	RFB4 dsFv (SSY-THW)	Pseudomonas exotoxin A (PE38)	mc-VC-PABC (enzyme cleavable)	R/R B-cell HCL
Pinatuzumab vedotin	Hu10F4 antibody	Monomethyl auristatin E	mc-VC-PABC (enzyme cleavable)	R/R B-cell NHL
Anti-CD22-NMS249	Hu10F4 antibody	PNU-159682	mc-VC-PABC (enzyme cleavable)	R/R B-cell NHL
Anti-CD22-(LC:K149C)-SN36248	Hu10F4 antibody	SN36248 × 2	maleimide linker (uncleavable)	B-cell NHL
Inotuzumab ozogamicin	G544 antibody	Calicheamicin (Calich-DMH)	hydrazone (acid-labile linker)	R/R B-ALL

dsFv disulfide-stabilized Fv fragment, R/R relapsed or refractory, HCL hairy cell leukemia, NHL non-Hodgkin lymphoma, ALL acute lymphoplastic leukemia