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. 2023 Oct 10;14:70. doi: 10.1186/s13293-023-00555-2

Fig. 6.

Fig. 6

Dual ET receptor antagonism eliminated the sex-difference in urinary ET-1 excretion. Urinary excretion rate of ET-1 (A) and NOx (B) in male and female rats fed a NS or a HS diet. Rats were either treated with or without the dual ET receptor antagonist (A-182086, 10 mg/kg/day). N = 7–13 per group. Two-way ANOVA with post hoc Sidak’s test. P values < 0.05 from post hoc test are displayed on graph. Endothelin receptor (ET), endothelin 1 (ET-1), high salt (HS), normal salt (NS), and total nitric oxide metabolites (NOx)