Table 2.

Overview of all included features

Descriptor group	Descriptor	# Features
Basic descriptors	Weight	1
	Charge	3
	Polarity	2
	Aromaticity	1
	Mean hydrophobicity	1
	Mean van der Waals volume	1
Residue composition	Amino acid composition	20
	Dipeptide composition	400
Physicochemical	Composition	21
properties	Transition	21
	Distribution	105
Sequence order effects	Pseudo amino acid composition	23

Descriptors are clustered in four groups given in the first column. The number of features for each descriptor is shown in the last column, summing up to 599 features in total. Detailed explanations for all descriptors can be found in Supplementary Data.