TABLE 2.

OS models within KRAS-variant: time-varying cetuximab effect

Time-varying model set	Variable	Comparison	HR (95% CI)	P
One year only	Cetuximab within 1 year	No Cetuximab (RL) vs. Cetuximab	3.37 (1.13–10.1)	0.0298
	Cetuximab >1 year	No Cetuximab (RL) vs. Cetuximab	0.45 (0.18–1.10)	0.0793
	Radiation level	>51 Gy–≤66 Gy vs. >66 Gy	1.43 (0.78–2.63)	0.2434
Years 1 and 2	Cetuximab within 1 year	No Cetuximab (RL) vs. Cetuximab	3.37 (1.13–10.1)	0.0299
	Cetuximab from year 1 to year 2	No Cetuximab (RL) vs. Cetuximab	0.37 (0.08–1.71)	0.2039
	Cetuximab >2 years	No Cetuximab (RL) vs. Cetuximab	0.49 (0.16–1.53)	0.2224
	Radiation level	>51 Gy–≤66 Gy vs. >66 Gy	1.43 (0.78–2.62)	0.2479
Years 1 and 4	Cetuximab within 1 year	No Cetuximab (RL) vs. Cetuximab	3.37 (1.13–10.1)	0.0299
	Cetuximab from year 1 to year 4	No Cetuximab (RL) vs. Cetuximab	0.33 (0.11–0.97)	0.0429
	Cetuximab >4 years	No Cetuximab (RL) vs. Cetuximab	1.66 (0.21–12.9)	0.6265
	Radiation level	Standard dose (RL) vs. High dose	1.42 (0.78–2.61)	0.2527