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. 2023 Oct 11;12:RP89083. doi: 10.7554/eLife.89083

Figure 5. Analysis of fragment length patterns of circulating tumor DNA (ctDNA) in plasma.

(A) Density plot of fragment length between cancer patients (red, n=499) and healthy participants (blue, n=1076) in the discovery cohort. Inset corresponds to an x-axis expansion of short fragment (<150 bp). (B) Ratio of short to long fragments across 22 autosomes. Each dot indicates a mean ratio for each bin in cancer patients (red) and healthy participants (blue).

Figure 5.

Figure 5—figure supplement 1. Correlations between bisulfite and non-bisulfite converted data.

Figure 5—figure supplement 1.

Pearson’s correlation analysis shows correlations of fragment length patterns (A) or end motifs (B) between bisulfite and non-bisulfite-treated cell-free DNA (cfDNA) from controls (n=3) and cancer samples (n=9).