Figure 6. Differences in 4-mer end motif between cancer and healthy cell-free DNA (cfDNA).

(A) Heatmap shows log₂ fold change of 256 4-mer end motifs in cancer patients (n=499) compared to healthy controls (n=1076). (B) Box plots showing the top 10 motifs with significant differences in frequency between cancer patients (red) and healthy controls (blue) using Wilcoxon rank-sum test with Bonferroni-adjusted p-value <0.0001.