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. 1998 Jul;42(7):1722–1725. doi: 10.1128/aac.42.7.1722

TABLE 2.

C. neoformans cell count in murine lung with pulmonary cryptococcosis after drug treatmenta

Treatment No. of cells (log10 CFU/g) after dose of:
0.8 mg/kg 2.0 mg/kg
Control (5% dextrose) 7.4 ± 0.04 7.4 ± 0.04
NS-718 6.7 ± 0.38b,c <3.0b,c
AmBisome 7.3 ± 0.38 7.6 ± 0.09
Fungizone 5.7 ± 0.51b,c,d NDe
a

Drug or dextrose was injected intravenously into 10 mice in each group, and the number of C. neoformans cells was counted 7 days after infection. The values shown are the means ± standard deviations. 

b

P < 0.05, compared to the respective control value (Scheffe multiple-comparison test). 

c

P < 0.05, compared to the respective AmBisome value (Scheffe multiple-comparison test). 

d

P < 0.05, compared to the respective NS-718 value (Schiffe multiple-comparison test). 

e

ND, not done.