TABLE 2.
Treatment | No. of cells (log10 CFU/g) after dose of:
|
|
---|---|---|
0.8 mg/kg | 2.0 mg/kg | |
Control (5% dextrose) | 7.4 ± 0.04 | 7.4 ± 0.04 |
NS-718 | 6.7 ± 0.38b,c | <3.0b,c |
AmBisome | 7.3 ± 0.38 | 7.6 ± 0.09 |
Fungizone | 5.7 ± 0.51b,c,d | NDe |
Drug or dextrose was injected intravenously into 10 mice in each group, and the number of C. neoformans cells was counted 7 days after infection. The values shown are the means ± standard deviations.
P < 0.05, compared to the respective control value (Scheffe multiple-comparison test).
P < 0.05, compared to the respective AmBisome value (Scheffe multiple-comparison test).
P < 0.05, compared to the respective NS-718 value (Schiffe multiple-comparison test).
ND, not done.