TABLE 1. Antithrombotic agents and its reversal agents.

	Drug	Reversal agent	Dose
Antiplatelet drugs	Aspirin, clopidogrel, cilostizol	Platelet	>3×109 platelet/L 1 U
Parenteral anticoagulants	Heparin	Protamine	1 mg IV per 100 U of heparin over last 4 hours (maximum 50 mg)
	Enoxaparin	Protamine	1 mg IV per 1 mg of LMWH (maximum 50 mg)
Oral anticoagulants	Warfarin	Vitamin K	1–2 mg IV or PO 2.5–10 mg q 12 hours
		FFP	Administer until corrected
		PCC	25 U/kg IV for INR 2–4, 35 U/kg IV for INR 4–6, 50 U/kg IV for INR >6
	Rivaroxaban	PCC	50 IU/kg IV
		Andexanet alfa	400–800 mg IV bolus, 480–960 mg infusion
	Apixaban	PCC	50 IU/kg IV
		Andexanet alfa	400 mg IV bolus, 480 mg infusion
	Edoxaban	PCC	50 IU/kg IV
		Andexanet alfa	800 mg IV bolus, 960 mg infusion
	Dabigatran	Idarucizumab	5g IV bolus

FFP: fresh-frozen plasma, PCC: prothrombin complex concentrate, INR: international normalized rat.