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. 2023 Oct 4;622(7982):329–338. doi: 10.1038/s41586-023-06592-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — (a) Effect of PCSK9 plasma protein level on lipids, cardiovascular diseases and stroke risk. (b) Comparison of PCSK9 plasma protein effect estimates based on genetic instruments from four different pQTL studies. Error bars indicate 95% confidence intervals around the effect size estimates. Sample sizes for studies from which summary statistics were derived are detailed in Supplementary Table 30.