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. 2023 Sep 27;622(7982):359–366. doi: 10.1038/s41586-023-06564-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Sources of the 611 NDD genes. b, Sources of the 425 NDD genes included in the screens. c, Expression trajectories in the human cerebral cortex of the selected 425 NDD genes using the BrainSpan dataset⁶⁰. Displayed are fitted (generalized additive model; denoted with dashed line) z-score normalized expression data with 99% confidence interval shown in grey (n = 425 genes; n = 419 cortical samples). d, e, Expression in hSO Dlxi1/2b::eGFP⁺ cells of screen hit genes compared with non-hit genes. e, Boxplot (horizontal line denotes median; lower and upper hinges correspond to the first and third quartiles; whiskers extend 1.5 times the interquartile range with outliers shown outside this range) representation of expression levels; non-hits (n = 392 genes) versus interneuron generation hits (n = 13 genes): P = 0.2013; non-hits versus interneuron migration hits (n = 33 genes): P = 0.404; two-sided Wilcoxon tests. f, Expression of screen hits summarized by cell cluster based on a single-cell RNA sequencing atlas of developing human cortex³⁰.