FIG. 8.

Distribution of ITZ in mdr1a knockout mouse organs after intravenous administration of this drug at a dose of 5 mg/kg. Shown are ITZ concentrations and K_p values for brain (A), liver (B), kidney (C), and lung (D) tissues. Each K_p value was calculated by dividing the organ ITZ concentration by the plasma ITZ concentration. Each point represents the mean ± SE (n = 3 to 4). Values found to be significantly different from control values by Student’s t test are indicated (∗, P < 0.05; ∗∗, P < 0.01; #, P < 0.005; ##, P < 0.001). Symbols: •, concentration, mdr1a −/− mice; ○, concentration, mdr1a +/+ mice; □, K_p value, mdr1a −/− mice; ▪, K_p value, mdr1a +/+ mice.