Table 2.
Heterogeneity and pleiotropy of epigenetic age and heart failure
| Exposure | Outcome | Q‐statistics | Pleiotropic test | ||
|---|---|---|---|---|---|
| MR–Egger | IVW | Egger_intercept | P value | ||
| GrimAge | HF | Q = 1.74E + 01, P = 6.88E − 01 | Q = 1.75E + 01, P = 7.37E − 01 | −2.12E − 03 | 7.65E − 01 |
| HannumAge | HF | Q = 3.23E + 01, P = 5.01E − 01 | Q = 3.24E + 01, P = 5.44E − 01 | −1.73E − 03 | 7.35E − 01 |
| HorvathAge | HF | Q = 5.50E + 01, P = 2.28E − 01 | Q = 5.50E + 01, P = 2.59E − 01 | 6.33E − 05 | 9.90E − 01 |
| PhenoAge | HF | Q = 3.20E + 01, P = 1.85E − 01 | Q = 3.92E + 01, P = 2.12E − 01 | 2.05E − 03 | 6.64E − 01 |
| HF | GrimAge | Q = 1.47E + 01, P = 1.18E − 02 | Q = 1.93E + 01, P = 3.64E − 03 | 1.67E − 01 | 2.65E − 01 |
| HF | HannumAge | Q = 4.18E + 01, P = 1.74E − 05 | Q = 4.44E + 01, P = 1.32E − 05 | −5.58E − 02 | 4.31E − 01 |
| HF | HorvathAge | Q = 1.35E + 01, P = 3.67E − 03 | Q = 1.42E + 01, P = 6.62E − 03 | 7.04E − 02 | 7.16E − 01 |
| HF | PhenoAge | Q = 9.95E + 00, P = 6.91E − 03 | Q = 1.03E + 01, P = 1.65E − 02 | −9.67E − 02 | 8.28E − 01 |
IVW, inverse‐variance weighted; MR, Mendelian randomization.