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. 2023 Aug 21;10(5):3077–3090. doi: 10.1002/ehf2.14492

Figure 6.

Figure 6

Calpain1 is a direct target of miR‐124‐3p. (A) The predicted binding sites for miR‐124‐3p in calpain1 mRNA. (B) MiR‐124‐3p significantly decreased the luciferase activity of wild‐type calpain1 (calpain1‐wt) but not mutant‐type calpain1 (calpain1‐mut) in 293A cells. (C) Expression of calpain1 mRNA decreased after overexpression of miR‐124‐3p. (D) Calpain1 activity decreased after overexpression of miR‐124‐3p. (E) Expression of calpain1 protein decreased after overexpression of miR‐124‐3p.