Table 1.
Patient characteristics, right ventricular myocardial work, and invasive pressure–volume loop measurements
| PAH/CTEPH | Control | P value | |
|---|---|---|---|
| Patients, n | 34 | 8 | |
| Male/female, n/n | 10/24 | 1/8 | 0.328 |
| Age, years | 66 [53–73] | 51 [37–62] | 0.044 |
| BMI, kg/m2 | 29 ± 7 | 28 ± 6 | 0.576 |
| Diagnosis, n (%) | |||
| PAH, Group I | 17 | ||
| CTEPH | 17 | ||
| Right heart catheterization | |||
| Mean pulmonary artery pressure, mmHg | 38 [28–50] | 17 [12–19] | <0.001 |
| Pulmonary vascular resistance, Wood units | 5.7 [3.4–8.1] | 1.1 [0.8–1.4] | <0.001 |
| Cardiac index, L/min/m2 | 2.6 ± 0.6 | 3.4 ± 0.8 | 0.003 |
| Pulmonary artery wedge pressure, mmHg | 9 ± 4 | 9 ± 3 | 0.635 |
| Echocardiography | |||
| RVGWI, mmHg% | 607 [412–820] | 498 [276–705] | 0.289 |
| RVGWW, mmHg% | 60 [30–115] | 24 [15–34] | 0.006 |
| RVGLS, % | −16 ± 5 a | −21 ± 3 | 0.010 |
| PASP, mmHg | 52 ± 19 | 28 ± 12 | 0.002 |
| DPAP, mmHg | 26 [19–31] | 15 [13–21] | 0.002 |
| Pressure–volume loop measurements | |||
| Ea, mmHg/mL | 0.65 [0.45–0.93] | 0.24 [0.16–0.26] | <0.001 |
| Ees, mmHg/mL | 0.73 [0.55–0.98] | 0.38 [0.26–0.62] | 0.003 |
| Ees/Ea ratio | 1.03 [0.90–1.44] | 1.63 [1.26–2.10] | 0.002 |
| Eed, mmHg/mL | 0.18 [0.14–0.27] | 0.14 [0.06–0.20] | 0.075 |
| SW, mmHg/mL | 2630 [2046–3292] | 1240 [1044–1428] | <0.001 |
BMI, body mass index; CTEPH, chronic thromboembolic pulmonary hypertension; DPAP, pulmonary artery diastolic pressure; Ea, arterial elastance; Eed, end‐diastolic elastance; Ees, end‐systolic elastance; PAH, pulmonary arterial hypertension; PASP, pulmonary artery systolic pressure; RVGLS, right ventricular global longitudinal strain; RVGWI, right ventricular global work index; RVGWW, right ventricular global wasted work; SW, stroke work.
Values represent mean ± standard deviation or median [interquartile range], unless otherwise specified.
a
34.