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. 2023 Oct 11;14:6384. doi: 10.1038/s41467-023-42040-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–d Records for the body weight (a), liver weight and the ratio of liver weight/body weight (%) (LW/BW) (P < 0.0001 by one-way ANOVA) (b), fasting blood glucose levels, fasting insulin levels, fasting insulin levels and homoeostasis model assessment of insulin resistance (HOMA-IR) index (P < 0.0001 by one-way ANOVA) (c) and glucose tolerance test (GTT) analysis (P < 0.0001 by one-way ANOVA) (d) of the HFHC-fed HKO (Trim26) mice, hepatocyte-specific Cebpd deletion-HKO (Cebpd) mice, hepatocyte-specific Trim26 and Cebpd double knockout-DHKO (Trim26-Cebpd) mice and Flox mice (n = 15 mice per group). e Liver lipid contents including triglyceride (TG) (P < 0.0001 by one-way ANOVA), total cholesterol (TC) (P < 0.0001 by 2 tailed t test) and non-esterified fatty acid (NEFA) (P < 0.0001 by one-way ANOVA) in the indicated group (n = 15 mice per group). f, g Pearson correlation analyses showing the correlations between serum tumour necrosis factor (TNF-α) levels and fasting blood glucose (f), and fasting insulin and ratio of liver weight/body weight (%) (g) in HKO (Trim26) HFHC, HKO (Cebpd) HFHC, DHKO (Trim26-Cebpd) HFHC and Flox HFHC group. P < 0.01 for all of these correlations (n = 15 per parameter; n = 45 in total; P < 0.0001 by one-way ANOVA). h Representative pictures of H&E staining, oil red O staining and NAS score (P < 0.0001 by one-way ANOVA) in indicated group (scale bars: magnification, 100×; n = 15 images per group for each staining). i Circle correlation analysis showing the correlation between a series of indicators in HKO (Trim26) HFHC, HKO (Cebpd) HFHC, DHKO (Trim26-Cebpd) HFHC and Flox HFHC group. j, k Representative pictures of immunohistochemical analysis of F4/80 (P < 0.0001 by one-way ANOVA) and CD11b (P < 0.0001 by one-way ANOVA) (scale bars: magnification, ×200; n = 15 images per group for each staining) (j) and sirius red (P < 0.0001 by one-way ANOVA) & masson staining (P < 0.0001 by one-way ANOVA) (scale bars: magnification, ×100; n = 15 images per group for each staining) (k)-indicated histological changes in liver, and corresponding hepatic hydroxyproline & collagen contents in HKO (Trim26) HFHC, HKO (Cebpd) HFHC, DHKO (Trim26-Cebpd) HFHC and Flox HFHC group. Data are expressed as mean ± SEM. The relevant experiments presented in this part were performed independently at least three times. P < 0.05 indicates statistical significance.