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. 2023 May 9;396(11):3087–3099. doi: 10.1007/s00210-023-02511-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Flowchart outlines all the steps taken to complete the process, as well as the inputs and outputs of each step. It provides a visual representation of the steps taken and is useful for tracking progress and ensuring that all steps are completed correctly. B Animal grouping design: each group contained 15 mice; Group I (negative control group); Group II (control + SOR); Group III (control + CLT); Group IV (control + SOR + CLT); Group V (HCC group); Group VI (HCC + SOR); Group VII (HCC + CLT); Group VIII (HCC + SOR + CLT). Abbreviation: CMC: carboxymethylcellulose; SOR: sorafenib; CLT: dicinnamoyl-L- tartaric acid; HCC: hepatocellular carcinoma