Fig. 5.

Multivariable analysis of TE risk by laboratory and clinical parameters. Data are based on assessments within 6 months before the TE index date. Patient numbers are reported as [TE cases, controls] per parameter. OR and 95% CIs are Wald’s estimates from multivariable conditional logistic regression model of risk of TE event. The increased risk of TE observed in patients receiving anticoagulation with no history of TE likely reflects prescribing decisions based on physician assessment of TE risk (ie, primary prophylaxis) rather than contributing to risk itself and should be interpreted accordingly. ^‡HDA defined as LDH ratio ≥ 1.5 × ULN, hemoglobin < 10 g/dL, and one of the following symptoms 6 months before and including the index date: abdominal pain, dyspnea, dysphagia, fatigue, hemoglobinuria, or erectile dysfunction. ^§Assessments based on the entire patient history from PNH diagnosis to index date. ^¶Recent is defined as within 6 months before the index date. GPI, glycosylphosphatidylinositol; HDA, high disease activity; LDH, lactate dehydrogenase; MAVE, major adverse vascular event; OR, odds ratio; TE, thromboembolic event; ULN, upper limit of normal