Table 1.
Frequency (%) of open clefts in synaptic profiles of dissociated cultures under different conditions.
| Control | High K+ | NMDA | APV | TTX/APV/CNQX | EGTA | |
|---|---|---|---|---|---|---|
| Exp 1 | 2% (50) | 20.7% (58) p < 0.005 | ||||
| Exp 2 | 0% (42) | 14.3% (70) p < 0.05 | ||||
| Exp 3 | 3.4% (87) | 18.9% (106) p < 0.005 | ||||
| Mean ± SEM | 1.8 ± 1.0 | 18.0 ± 1.9 | ||||
| Exp 1 | 5.2% (155) | 12.4% (89) p < 0.05 | ||||
| Exp 2 | 5.3% (57) | 19.5% (41) p < 0.05 vs. control | 3.1% (64) p < 0.01 vs. NMDA | |||
| Exp 3 | 25% (44) | 2.1% (48) p < 0.005 | ||||
| Mean ± SEM | 5.3 ± 0.1 | 19.0 ± 3.6 | 2.6 ± 0.5 | |||
| Exp 1 | 3.6% (55) | 0 (44) p = 0.2 | ||||
| Exp 2 | 4.4% (45) | 0 (40) p = 0.18 | ||||
| Exp 3 | 3.8% (78) | 0 (74) p = 0.09 | ||||
| Mean ± SEM | 3.9 ± 0.2 | 0 | ||||
| Exp 1 | 3.8% (131) | 16.0% (169) p < 0.001 | ||||
| Exp 2 | 2.3% (44) | 17.3% (52) P < 0.05 | ||||
| Exp 3 | 5.5% (55) | 20% (40) p < 0.05 vs. control | 16.4% (67) p = 0.06 vs. control | |||
| Mean ± SEM | 4.0 ± 1.1 | 16.6 ± 0.4 |
P values of Chi-Square test of independence within each experiment are listed in each row.
(n) = number of clef edges scored.