Table 3.
Associations between HLA and Graves’ orbitopathy in Asian population.
| First author | Ref. | Year | Population | Method | No. of GO patients | No. of GD patients | No. of healthy controls |
High risk HLA | Protective HLA |
|---|---|---|---|---|---|---|---|---|---|
| Inoue D | (59) | 1991 | Japanese | serological | 23 | 88 | 186 | DQw3, DPw2 |
NR |
| Inoue D | (45) | 1992 | Japanese | serological | 42 | 88 | 186 | -DQw4 (+) and -A31 (–) -B5 (+) and -Dw12 (+) -A11 (+) and -DPw2 (+) |
NR |
| Ohtsuka K and Nakamura Y | (60) | 1998 | Japanese | serological | 48 | 94 | 767 | DR14, DQ1 |
B35, B54, DR4, DQ4 |
| Jang HW | (56) | 2011 | Korean | PCR-SBT | 13 | 120 | 200 | DRB1*12:01 | NR |
| Mehraji Z | (61) | 2017 | Iranian | SSP | 45 | 80 | 180 | none | NR |
| Shin et al. | (14) | 2019 | Korean | NGS | 35 | 71 | 142 | C*03:03 | B*54:01 |
| Huang et al. | (62) | 2021 | Chinese | NGS | 82 | 272 | 411 |
B*38:02
DRB1*16:02 DQA1*01:02 DQB1*05:02 |
NR |
PCR, polymerase chain reaction; SBT, sequence based typing; SSP, sequence specific primers; NGS, next generation sequencing; NR, not reported.