Table 2.
Conductance-voltage (GV) relationships of rescued hERG potassium channels
Condition (n) | GV |
|
---|---|---|
V1/2 (mV) | k (slope) | |
WT hERG (27) | −7.5 ± 1.5 | 8.7 ± 0.3 |
Q702x + Gln-tRNA (21) | −11.2 ± 1.9 | 8.9 ± 0.3 |
R863X + Arg-tRNA (15) | −18.8 ± 3.4∗ | 12.6 ± 0.8∗ |
W1001X (17) | −14.2 ± 1.7 | 10.7 ± 0.3 |
W1001X + Trp-tRNA (14) | −5.1 ± 1.4 | 9.1 ± 0.3 |
W1001X + Gly-tRNA (15) | −16.7 ± 3.1∗ | 12.2 ± 1.1∗ |
Values are presented as the mean ± SEM. Statistical significance was set at p < 0.05 and is marked with an asterisk. The data in this table were used to generate Figure 3.