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. 2023 May 24;13(9):1058–1069. doi: 10.1016/j.jpha.2023.05.012

Table 1.

Key pathways, targets and metabolites of Eight Zhes Decoction (EZD) against nonalcoholic fatty liver disease.

Main pathway Core targets Key metabolites
Linoleic acid metabolism PLA2G2A, CYP2C8, CYP3A4, CYP2C9, CYP1A2, PLA2G4A 12,13-cis-epoxyoctadecenoic acid, 9,10-epoxyoctadecenoic acid, phosphatidylcholine
Arachidonic acid metabolism PLA2G2A, CYP2C8, ALOX12, CYP2C9, PLA2G4A phosphatidylcholine, 12(S)-hydroxyeicosatetraenoic acid, 15(S)-hydroxyeicosatetraenoic acid, 5(S)-hydroxyeicosatetraenoic acid, leukotriene B4, prostaglandin E2
Glycerolipid metabolism CEL, DGAT1 1,2-diacyl-sn-glycerol, triglyceride
Glycerophospholipid metabolism PLA2G2A, ACHE 1-acyl-sn-glycero-3-phosphocholine, phosphatidylcholine, 1,2-diacyl-sn-glycerol, phosphatidylethanolamine