Figure 1. Participant Flow and Study Design.

^aRecommendation: “However, simvastatin may not provide much benefit for people who are your age. Therefore, I recommend that you stop taking simvastatin.”

^bRecommendation: “However, simvastatin may cause more problems in people who are your age. Therefore, I recommend that you stop taking simvastatin.”

^cRecommendation: “However, simvastatin may not provide much benefit and it may cause more problems among people who are your age. Therefore, I recommend that you stop taking simvastatin.”

^dRecommendation: “However, lansoprazole may not provide much benefit for people who take it for more than a few months. Therefore, I recommend that you stop taking lansoprazole.”

^eRecommendation: “However, lansoprazole may cause problems in people who take the medication for more than a few months. Therefore, I recommend that you stop taking lansoprazole.”

^fRecommendation: “However, lansoprazole may not provide much benefit and it can cause problems in people who take the medication for more than a few months. Therefore, I recommend that you stop taking lansoprazole.”

^gParticipants who agreed or strongly agreed with deprescribing (n = 4366), provided a free-text rationale without any understandable words (n = 13), or indicated agreement with deprescribing in their free-text rationale (n = 33) were excluded.