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. 2023 Sep 22;26(10):108018. doi: 10.1016/j.isci.2023.108018

Figure 2.

Figure 2

hHNF1Amut/- mice developed hepatomegaly, lipid accumulation in liver

(A) Representative images of livers of 20-week-old male mice. Scale bar: 1 cm.

(B) Ratio of liver weight to body weight (n = 6 for hHNF1A−/− group, n = 9 for hHNF1Amut/- group).

(C) Representative images of Hematoxylin and eosin (H&E) staining, Oil red staining of livers of 20-week-old male mice. Scale bar: 50μm.

(D‒F) Levels of triglyceride (TG) (D), total cholesterol (TC) (E) and free cholesterol (FC) (F) in livers of 20-week-old male mice (n = 5 for hHNF1A−/− group, n = 7 for hHNF1Amut/- group).

(G) Protein levels of fatty acid synthase (FASN), sterol regulatory element binding protein 1 (SREBP-1C), CD36 molecule (CD36), peroxisome proliferator activated receptor gamma (PPARγ), stearoyl-coenzyme A desaturase 1 (SCD1) and β-ACTIN expressions in livers of hHNF1A−/− and hHNF1Amut/- mice (n = 5 for each group). All data are presented as mean ± SD. ∗p < 0.05; ∗∗p < 0.01 by an unpaired two-tailed t test. See also Figures S2 and S8.