Figure 3.

Transcriptome analysis of hHNF1A^mut/- vs. hHNF1A^−/− mice

(A) Volcano map of transcriptome analysis of livers of 40-week-old male mice (padj<=0.05, |log2FoldChange>=1) (n = 3 for each group). The TOP upregulated or downregulated genes were labeled.

(B) mRNA levels of TOP differential expressed genes (DEG) from transcriptome analysis in liver. (n = 9 for each group). Data are shown by mean ± SD. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001 by an unpaired two-tailed t test.

(C) Networks of enriched terms across upregulated gene expressions in transcriptome analysis (padj <0.01). See also Figure S3.