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. 2023 Sep 22;26(10):108018. doi: 10.1016/j.isci.2023.108018

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Overexpression of HNF1α or inhibition of CFD attenuated triglyceride accumulation in free fatty acid (FFA) induced HepG2 cells and primary hepatocytes of hHNF1A^mut/- mice

(A and B) The TG content in FFA-pretreated HepG2 cells transfected with WT HNF1α and HNF1α P291fsinsC mutation (A) or treated with CFD inhibitor ACH-4471 (B).

(C) The knockdown efficiency of three mouse Cfd siRNAs.

(D and E) The TG level (D) and the expression of genes related to de novo lipogenesis (Fasn, Srebp-1c, Scd1) and fatty acid uptake (Pparg, Cd36 and Fatp2) (E) of the primary hepatocytes of hHNF1A^mut/- mice transfected with siCfd1 and siCfd2. All data were presented as mean ± SD. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 by Ordinary one-way ANOVA test.