Table 2.
Differences in OCT/OCTA measurements between MA and healthy controls.
| Outcome variables | Number of studies | Number of eyes | WMD + 95% CI | Value of p | I2 test (%) | Egger’s test | |||
|---|---|---|---|---|---|---|---|---|---|
| MA | HC | ||||||||
| FAZ | FAZ area | 5 | 188 | 190 | 0.053 (0.033,0.073) | 0.000 | 21.80% | 0.178 | |
| FAZ perimeter | 2 | 62 | 62 | 0.332 (0.117,0.546) | 0.002 | 0.00% | - | ||
| MPD | SCP | Whole image | 3 | 118 | 120 | −0.345 (−0.952,0.262) | 0.265 | 48.90% | 0.205 |
| Hemi-superior | 3 | 118 | 120 | −0.544 (−1.182,0.094) | 0.095 | 20.30% | 0.024 | ||
| Hemi-inferior | 3 | 118 | 120 | −0.482 (−1.138,0.175) | 0.150 | 0.00% | 0.203 | ||
| Fovea | 3 | 118 | 120 | −2.714 (−7.131,1.704) | 0.229 | 78.80% | 0.027 | ||
| Parafovea | 3 | 118 | 120 | −1.420 (−3.291,0.452) | 0.137 | 64.10% | 0.253 | ||
| Perifovea | 2 | 58 | 64 | −1.483 (−2.787,-0.179) | 0.026 | 0.00% | - | ||
| DCP | Whole image | 3 | 118 | 120 | −1.460 (−2.324,-0.595) | 0.001 | 0.00% | 0.573 | |
| Hemi-superior | 3 | 118 | 120 | −1.257 (−1.961,-0.554) | 0.000 | 40.00% | 0.123 | ||
| Hemi-inferior | 3 | 118 | 120 | −1.081 (−1.818,-0.344) | 0.004 | 0.00% | 0.547 | ||
| Fovea | 3 | 118 | 120 | −4.045 (−8.144,0.053) | 0.053 | 73.10% | 0.145 | ||
| Parafovea | 3 | 118 | 120 | −1.193 (−1.875,-0.512) | 0.001 | 0.00% | 0.080 | ||
| Perifovea | 2 | 58 | 64 | −2.041 (−4.001,-0.082) | 0.041 | 0.00% | - | ||
| RPD | Whole image | 3 | 118 | 120 | −2.031 (−4.927,0.866) | 0.169 | 92.60% | 0.288 | |
| Inside disk | 3 | 118 | 120 | −2.602 (−4.135,-1.069) | 0.001 | 0.00% | 0.178 | ||
| Peripapillary | Average | 3 | 118 | 120 | −2.295 (−5.220,0.630) | 0.124 | 88.00% | 0.376 | |
| Superior | 3 | 96 | 102 | −3.194 (−6.766,0.379) | 0.080 | 89.90% | 0.353 | ||
| Inferior | 3 | 96 | 102 | −1.748 (−3.550,0.055) | 0.057 | 59.30% | 0.006 | ||
| Temporal | 4 | 156 | 158 | −2.134 (−4.276,0.009) | 0.051 | 85.50% | 0.131 | ||
| Nasal | 4 | 156 | 158 | −0.924 (−2.408,0.560) | 0.222 | 57.30% | 0.421 | ||
| pRNFL | Average | 6 | 198 | 262 | −6.087 (−9.856,-2.318) | 0.002 | 68.80% | 0.150 | |
| Hemi-superior | 1 | 28 | 34 | −8.900 (−13.647,-4.153) | 0.000 | - | - | ||
| Hemi-inferior | 1 | 28 | 34 | −6.000 (−9.796,-2.204) | 0.002 | - | - | ||
| Superior | 3 | 110 | 124 | −12.053 (−21.441,-2.666) | 0.012 | 86.20% | 0.977 | ||
| Inferior | 3 | 110 | 124 | −7.979 (−14.983,-0.975) | 0.026 | 86.20% | 0.367 | ||
| Temporal | 7 | 260 | 314 | −4.388 (−6.097,-2.678) | 0.000 | 0.00% | 0.322 | ||
| Nasal | 7 | 260 | 314 | −8.089 (−12.564,-3.615) | 0.000 | 74.80% | 0.435 | ||
| Superior-temporal | 3 | 120 | 160 | −0.640 (−4.921,3.641) | 0.770 | 0.00% | 0.389 | ||
| Inferior-temporal | 3 | 120 | 160 | −8.803 (−13.405,-4.202) | 0.000 | 7.20% | 0.477 | ||
| Superior-nasal | 3 | 120 | 160 | −4.483 (−9.441,0.476) | 0.076 | 0.00% | 0.790 | ||
| Inferior-nasal | 3 | 120 | 160 | −7.428 (−12.842,-2.015) | 0.007 | 0.00% | 0.610 | ||
MA, migraine with aura; HC, healthy control; WMD, weighted mean difference; CI, confidence interval; FAZ, foveal avascular zone; MPD, macular perfusion density; RPD, radial peripapillary capillary perfusion density; pRNFL, peripapillary retinal nerve fiber layer; SCP, superficial capillary plexus; DCP, deep capillary plexus. The bold values means the difference between the two groups is statistically significant.