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. 2023 Sep 28;10:1277530. doi: 10.3389/fmolb.2023.1277530

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Copyright © 2023 Zhang, Dong, Sun, Zhong, Xiong, Gong, Li, Lin and Zhuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a stable risk model. (A,B) Sample distribution characteristics of two bulk RNA-seq cohorts before and after removal of batch effects. (C) LASSO regression screening for significant variables affecting prognosis. (D) Forest plot showing the results of multivariate COX analysis. (E) Distribution of coefficient values of model genes. (F) A forest plot was used to validate the constructed riskscore as an independent prognostic model. (G) The survival differences and PCA sample distribution of different risk groups in TCGA-TRAIN, TCGA-TEST, TCGA-ALL, and GEO53624, respectively, were presented. (H) Survival validation of the model genes. Note: # represents p < 0.05; ## represents p < 0.01; ### represents p < 0.001.