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. 2023 Oct 12;222(11):e202310012. doi: 10.1083/jcb.202310012

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© 2023 Dinet and Michelot

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Figure 1. — Schematic representation of the regulation of ADF7 and ADF10 in Arabidopsis thaliana pollen tubes. Pollen tube growth in A. thaliana depends on the formation of pH gradients along its main axis. The gradual increase in pH from tip to base is important for the regulation of several cellular processes, including the assembly and dynamics of the actin cytoskeleton. ADF7 and ADF10, two predominantly expressed isoforms of the ADF/cofilin protein family, are sensitive to these pH differences. While ADF7 binds to filamentous actin and functions at low pH, ADF10 prefers high pH. As a consequence, ADF7 and ADF10 partially segregate to different regions of the pollen tube and act on different actin networks. In particular, ADF7 plays an important role in enhancing actin filament turnover in the apical region of low pH, while ADF10 acts primarily on the denser actin networks of a subapical region.