Table 2.
Odds ratios and 95% confidence intervals for NAFLD according to the tertiles of the predicted pro-inflammatory hs-CRP score for the sex-combined model, male-specific model, and female-specific model
| Regression model | Tertiles of the predicted pro-inflammatory hs-CRP score |
|||
|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | P trend | |
| Sex-combined modela | ||||
| NAFLD cases/total | 34/358 | 81/359 | 205/359 | |
| Age-adjusted | 1.00 | 3.53 (2.25, 5.55) | 19.25 (12.02, 30.82) | <0.0001 |
| Model 1b | 3.30 (2.06, 5.30) | 18.25 (10.47, 31.81) | <0.0001 | |
| Males in sex-combined model | ||||
| NAFLD cases/total | 11/59 | 45/148 | 154/260 | |
| Age-adjusted | 1.00 | 2.47 (1.15, 5.30) | 10.30 (4.78, 22.21) | <0.0001 |
| Model 2c | 3.08 (1.39, 6.82) | 16.64 (6.99, 39.65) | <0.0001 | |
| Females in sex-combined model | ||||
| NAFLD cases/total | 23/299 | 36/211 | 51/99 | |
| Age-adjusted | 1.00 | 2.79 (1.53, 5.12) | 15.85 (7.73, 32.48) | <0.0001 |
| Model 3d | 2.81 (1.52, 5.21) | 16.70 (7.80, 35.74) | <0.0001 | |
| Male-specific modele | ||||
| NAFLD cases/total | 48/155 | 69/156 | 93/156 | |
| Age-adjusted | 1.00 | 1.77 (1.11, 2.82) | 3.29 (2.06, 5.24) | <0.0001 |
| Model 2 | 1.77 (1.10, 2.84) | 3.26 (2.02, 5.28) | <0.0001 | |
| Female-specific modelf | ||||
| NAFLD cases/total | 11/203 | 25/203 | 74/203 | |
| Age-adjusted | 1.00 | 3.00 (1.38, 6.53) | 14.83 (6.48, 33.93) | <0.0001 |
| Model 3 | 3.03 (1.39, 6.62) | 16.71 (7.05, 39.63) | <0.0001 | |
NAFLD: non-alcoholic fatty liver disease; hs-CRP: high-sensitivity C-reactive protein.
Tertiles of the predicted pro-inflammatory hs-CRP scores were generated for men and women combined in a sex-combined model.
Model 1 was adjusted for age (continuous, years), sex (males or females), current alcohol drinking (no or yes), smoking (no, past or current), exercise (none, <840 MET-minutes/week or ≥840 MET-minutes/week), and highest education completed (high school and less, or college education and above).
Model 2 was adjusted for age (continuous, years), current alcohol drinking (no or yes), smoking (no, past or current), exercise (none, <840 MET-minutes/week or ≥840 MET-minutes/week), and highest education completed (high school and less, or college education and above).
Model 3 was adjusted for age (continuous, years), current alcohol drinking (no or yes), smoking (no, past or current), exercise (none, <840 MET-minutes/week or ≥840 MET-minutes/week), highest education completed (high school and less or college education and above), and menopausal status (premenopausal or postmenopausal).
Tertiles of the predicted pro-inflammatory hs-CRP scores were generated among men only in a male-specific model.
Tertiles of the predicted pro-inflammatory hs-CRP scores were generated for women only in a female-specific model.