Table 2. Physical and biological features and functions of lipoproteins.
| Category | Density (g/mL) |
Diameter (nm) |
Main lipid components (%) | Apoliprotein | Main source |
Function | |||||
| TG | Cholesteryl- ester |
Phospho- lipid |
Cholesterol | Main | Other | ||||||
| CM: chylomicron; HDL: high-density lipoprotein; IDL: intermediate-density lipoprotein; LDL: low-density lipoprotein; Lp(a): lipoprotein (a); VLDL: very low-density lipoprotein. | |||||||||||
| CM | < 0.950 | 80–100 | 90–95 | 2–4 | 2–6 | 1 | B48 | A1, A2, A4, A5 | Synthesized by the small intestine | Transport of TG and cholesterol from food from the small intestine to other tissues. | |
| VLDL | 0.950–1.006 | 30–80 | 50–65 | 8–14 | 12–16 | 4–7 | B100 | A1, C2, C3, E, A5 | Synthesized by the liver | Transport of endogenous TG to peripheral tissues and release of free fatty acids after hydrolysis by lipase | |
| IDL | 1.006–1.019 | 25–30 | 25–40 | 20–35 | 16–24 | 7–11 | B100 | C2, C3, E | TG in VLDL is formed after hydrolysis by lipase | LDL precursor, partially metabolized by the liver | |
| LDL | 1.019–1.063 | 20–25 | 4–6 | 34–35 | 22–26 | 6–15 | B100 | TG in VLDL and IDL is formed after hydrolysis by lipase | The main carrier of cholesterol, mediated by LDL receptors and taken up and utilized by peripheral tissues | ||
| HDL | 1.063–1.210 | 8–13 | 7 | 10–20 | 55 | 5 | A1 | A2, C3, E, M | Mainly synthesized by the liver and small intestine | Facilitates cholesterol removal from peripheral tissues and transports cholesterol to the liver or other tissues for redistribution | |
| Lp (a) | 1.055–1.085 | 25–30 | 4–8 | 35–46 | 17–24 | 6–9 | Apo(a) | B100 | Complex formation of Apo(a) with LDL via disulfide bonds in the liver or extra-hepatically | Function has not been fully understood yet. | |