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. 2023 Sep 28;20(9):621–663. doi: 10.26599/1671-5411.2023.09.008

Table 2. Physical and biological features and functions of lipoproteins.

Category Density
(g/mL)
Diameter
(nm)
Main lipid components (%) Apoliprotein Main
source
Function
TG Cholesteryl-
ester
Phospho-
lipid
Cholesterol Main Other
CM: chylomicron; HDL: high-density lipoprotein; IDL: intermediate-density lipoprotein; LDL: low-density lipoprotein; Lp(a): lipoprotein (a); VLDL: very low-density lipoprotein.
CM < 0.950 80–100 90–95 2–4 2–6 1 B48 A1, A2, A4, A5 Synthesized by the small intestine Transport of TG and cholesterol from food from the small intestine to other tissues.
VLDL 0.950–1.006 30–80 50–65 8–14 12–16 4–7 B100 A1, C2, C3, E, A5 Synthesized by the liver Transport of endogenous TG to peripheral tissues and release of free fatty acids after hydrolysis by lipase
IDL 1.006–1.019 25–30 25–40 20–35 16–24 7–11 B100 C2, C3, E TG in VLDL is formed after hydrolysis by lipase LDL precursor, partially metabolized by the liver
LDL 1.019–1.063 20–25 4–6 34–35 22–26 6–15 B100 TG in VLDL and IDL is formed after hydrolysis by lipase The main carrier of cholesterol, mediated by LDL receptors and taken up and utilized by peripheral tissues
HDL 1.063–1.210 8–13 7 10–20 55 5 A1 A2, C3, E, M Mainly synthesized by the liver and small intestine Facilitates cholesterol removal from peripheral tissues and transports cholesterol to the liver or other tissues for redistribution
Lp (a) 1.055–1.085 25–30 4–8 35–46 17–24 6–9 Apo(a) B100 Complex formation of Apo(a) with LDL via disulfide bonds in the liver or extra-hepatically Function has not been fully understood yet.