Supplementary Table S1.

Search Strategy

Number	Searches	Results
1	exp Cicatrix/ and (skin or cutaneous or hypertrophic or surg∗ or wound∗).ti,ab,hw,kw.	84,121
2	(((skin or cutaneous or hypertrophic or surg∗ or wound∗) adj4 (cicatrices or cicatrix or cicatrization or fibrosis or fibrotic or scar or scarring or scars)) or keloid or keloidal or keloide or keloides or keloids).ti,ab,hw,kw.	65,327
3	1 or 2	120,220
4	exp Angiotensin-Converting Enzyme Inhibitors/	239,514
5	("ACE inhibitor∗" or alacepril or altiopril or amlodipine or ancovenin or "angiotensin converting enzyme antagonist∗" or "angiotensin converting enzyme inhibiting agent∗" or "angiotensin converting enzyme inhibiting drug∗" or "angiotensin converting enzyme inhibiting medication∗" or "angiotensin converting enzyme inhibiting therap∗" or "angiotensin converting enzyme inhibiting treatment∗" or "angiotensin converting enzyme inhibitor∗" or "angiotensin i converting enzyme inhibitor∗" or "angiotensin i-converting enzyme inhibitor∗" or "angiotensin-converting enzyme antagonist∗" or "Angiotensin-Converting Enzyme Inhibitor∗" or "atorvastatin plus ramipril" or benazepril or benazeprilat or Captopril or ceranapril or Cilazapril or cilazaprilat or "converting enzyme inhibitor∗" or deacetylalacepril or delapril or "diltiazem plus enalapril maleate" or "dipeptidyl carboxypeptidase i inhibitor∗" or "dipeptidyl carboxypeptidase inhibitor∗" or Enalapril or Enalaprilat or epicaptopril or fasidotril or fasidotrilat or "felodipine plus ramipril" or foroxymithine or Fosinopril or fosinoprilat or gemopatrilat or "hydrochlorothiazide plus lisinopril" or "hydrochlorothiazide plus moexipril" or "hydrochlorothiazide plus quinapril" or "hydrochlorothiazide plus ramipril" or idrapril or ilepatril or imidapril or imidaprilat or "indapamide plus perindopril" or indolapril or "kininase ii antagonist∗" or "kininase ii inhibitor∗" or libenzapril or Lisinopril or "lisinopril plus torasemdie" or moexipril or moexiprilat or omapatrilat or pentopril or pentoprilat or "peptidyl dipeptidase inhibitor∗" or "peptidyldipeptide hydrolase inhibitor∗" or Perindopril or perindoprilat or pivopril or Quinapril or quinaprilat or Ramipril or ramiprilat or rentiapril or "s nitrosocaptopril" or sampatrilat or spirapril or spiraprilat or temocapril or temocaprilat or Teprotide or trandolapril or "trandolapril plus verapamil" or trandolaprilat or utibapril or utibaprilat or "vasopeptidase inhibitor∗" or zabicipril or zabiciprilat or zofenopril or zofenoprilat).ti,ab,hw,kw.	300,918
6	exp Angiotensin II/ag [Agonists]	31
7	exp angiotensin 2 receptor antagonist/	7,877
8	("Angiotensin 2 agonist∗" or "Angiotensin 2 block∗" or "angiotensin 2 receptor agonist∗" or "angiotensin 2 receptor antagonist∗" or "angiotensin 2 receptor block∗" or "angiotensin AT2 agonist∗" or "angiotensin AT2 antagonist∗" or "angiotensin AT2 block∗" or "angiotensin AT2 receptor agonist∗" or "angiotensin AT2 receptor antagonist∗" or "angiotensin AT2 receptor block∗" or "Angiotensin II agonist∗" or "Angiotensin II block∗" or "angiotensin II type 2 receptor agonist∗" or "angiotensin II type 2 receptor antagonist∗" or "angiotensin II type 2 receptor block∗" or "AT2 agonist∗" or "AT2 antagonist∗" or "AT2 block∗" or "AT2 receptor agonist∗" or "AT2 receptor antagonist∗" or "AT2 receptor block∗" or Azilsartan or Candesartan or Eprosartan or Irbesartan or Losartan or Olmesartan or Telmisartan or Valsartan).ti,ab,hw,kw.	96,387
9	or/4-8	356,594
10	3 and 9	629
11	(exp animals/ or exp nonhuman/) not exp humans/	11,678,555
12	((alpaca or alpacas or amphibian or amphibians or animal or animals or antelope or armadillo or armadillos or avian or baboon or baboons or beagle or beagles or bee or bees or bird or birds or bison or bovine or buffalo or buffaloes or buffalos or "c elegans" or "Caenorhabditis elegans" or camel or camels or canine or canines or carp or cats or cattle or chick or chicken or chickens or chicks or chimp or chimpanze or chimpanzees or chimps or cow or cows or "D melanogaster" or "dairy calf" or "dairy calves" or deer or dog or dogs or donkey or donkeys or drosophila or "Drosophila melanogaster" or duck or duckling or ducklings or ducks or equid or equids or equine or equines or feline or felines or ferret or ferrets or finch or finches or fish or flatworm or flatworms or fox or foxes or frog or frogs or "fruit flies" or "fruit fly" or "G mellonella" or "Galleria mellonella" or geese or gerbil or gerbils or goat or goats or goose or gorilla or gorillas or hamster or hamsters or hare or hares or heifer or heifers or horse or horses or insect or insects or jellyfish or kangaroo or kangaroos or kitten or kittens or lagomorph or lagomorphs or lamb or lambs or llama or llamas or macaque or macaques or macaw or macaws or marmoset or marmosets or mice or minipig or minipigs or mink or minks or monkey or monkeys or mouse or mule or mules or nematode or nematodes or octopus or octopuses or orangutan or "orang-utan" or orangutans or "orang-utans" or oxen or parrot or parrots or pig or pigeon or pigeons or piglet or piglets or pigs or porcine or primate or primates or quail or rabbit or rabbits or rat or rats or reptile or reptiles or rodent or rodents or ruminant or ruminants or salmon or sheep or shrimp or slug or slugs or swine or tamarin or tamarins or toad or toads or trout or urchin or urchins or vole or voles or waxworm or waxworms or worm or worms or xenopus or "zebra fish" or zebrafish) not (human or humans or patient or patients)).ti,ab,hw,kw.	9,999,103
13	10 not (11 or 12)	536
14	limit 13 to (editorial or erratum or note or addresses or autobiography or bibliography or biography or blogs or comment or dictionary or directory or interactive tutorial or interview or lectures or legal cases or legislation or news or newspaper article or overall or patient education handout or periodical index or portraits or published erratum or video-audio media or webcasts) [Limit not valid in CCTR,CDSR,Embase,Ovid MEDLINE(R),Ovid MEDLINE(R) Daily Update,Ovid MEDLINE(R) PubMed not MEDLINE,Ovid MEDLINE(R) In-Process,Ovid MEDLINE(R) Publisher; records were retained]	12
15	13 not 14	524
16	remove duplicates from 15	461